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Pharmacological treatment of nausea and vomiting in pregnancy 

Click here for helpful information regarding nausea and vomiting (N&V) in pregnancy, including non-pharmacological advice and information. 

It is recommended to trial ceasing a pregnancy multivitamin if you are experiencing N&V in pregnancy as this may be contributing. Importantly you should continue to take iodine 150mcg and folic acid 500mcg daily (or alternative dose if recommended by your doctor) for the first trimester. 

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Anti-nausea medications, also known as antiemetics are commonly recommended for mild, moderate and severe nausea and/or vomiting in pregnancy. Several large systematic reviews demonstrate the use of commonly prescribed Vitamin B6, doxylamine, metclopramide and Stemetil do not increase the risk of birth defects. Evidence into the antiemetic, ondansetron, remains conflicting between studies but it does not appear to increase the risk of birth defects. ​

Royal Women's Hospital recommends progressing through the following list from top to bottom, until nausea and vomiting is controlled. 

  • Short term use of ginger (<1000mg daily) can be safely taken. This is available over the counter (OTC) 

  • Vitamin B6 (pyridoxine) – 25mg  (OTC) daily, in the morning, midday and at night. Add doxylamine (Restavit) 25mg orally at night. Increase Restavit as tolerated to 12.5mg in the morning and at midday and 25mg at night

  • Metocloperamide (Maxolon, Pramin) 10mg orally three times a day OR Stemetil 5-10mg orally 2-3 times per day - take as directed initially, and titrate down once nausea and vomiting well managed

  • Ondansetron 4-8mg orally (tablet or wafer) two or three times a day ; take as directed initially, and titrate down once nausea and vomiting well managed

** Before moving down the list to trial the next type of antiemetic, you should cease the previous one. 

Please call our rooms if you have any questions regarding treatment for N&V. 

Click here for more information about supporting your emotional and mental health during pregnancy 

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